Synthetic Motor Oil and high-bypass secondary oil filters?

I have seen the stickers on peoples' cars and read extensively why I should buy the products. I am wondering if anyone else has feedback or firsthand experience using synthetic oils (ie. Amsoil) along with the high-bypass filter on gas or diesel engines? Please ask if you need more information to answer the question. I am thinking proactively towards - theoretically - extending the engine life even further. I would use the secondary high-bypass filtering and oil condition monitoring to watch for metals/chemical imbalances present as the engine hours and miles continue to accrue. Seemingly $1,000 (approximate cost for filter kit and oil) now could save the outlay of several thousand dollars for a rebuild. At least delay it for a longer period of time. Thanks all.

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